Title : Lipid IVa incompletely activates MyD88-independent Toll-like receptor 4 signaling in mouse macrophage cell lines.

Pub. Date : 2013 Apr

PMID : 23620183






2 Functional Relationships(s)
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1 We investigated the difference in the effect of synthetic lipid A compounds on MyD88-dependent and -independent Toll-like receptor 4 (TLR4) signaling in mouse macrophage cells. Lipid A myeloid differentiation primary response gene 88 Mus musculus
2 A maximum level of NF-kappaB activation, which is involved in IL-1beta gene transcription, was also induced to a similar level by these four lipid A compounds, while the maximum level of IFN-beta promoter activity induced during MyD88-independent signaling was also less than 50% for lipid IVa stimulation compared with other lipid A compounds. Lipid A myeloid differentiation primary response gene 88 Mus musculus