Pub. Date : 2013 Jun
PMID : 23619509
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MATERIALS AND METHODS: We examined the effects of BDNF single nucleotide polymorphisms (SNPs) in response to the antidepressants paroxetine and mirtazapine in a sample of 246 geriatric patients with major depression, treated in a double-blind, randomized, 8-week clinical trial. | Paroxetine | brain derived neurotrophic factor | Homo sapiens |
| 2 | RESULTS: BDNF genetic variation had a significant effect on the efficacy of paroxetine, with patients carrying the Met allele showing impaired response. | Paroxetine | brain derived neurotrophic factor | Homo sapiens |
| 3 | SNPs at the CREB1 locus, which encodes a transcription factor important in BDNF signaling, also predicted response to paroxetine. | Paroxetine | brain derived neurotrophic factor | Homo sapiens |
| 4 | Furthermore, we found a significant gene-gene interaction between BDNF and CREB1 that affected response to paroxetine. | Paroxetine | brain derived neurotrophic factor | Homo sapiens |