Title : 2,3,7,8-TCDD induces neurotoxicity and neuronal apoptosis in the rat brain cortex and PC12 cell line through the down-regulation of the Wnt/β-catenin signaling pathway.

Pub. Date : 2013 Jul

PMID : 23619006






1 Functional Relationships(s)
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1 Interestingly the application of lithium chloride, a GSK-3beta inhibitor, reversed the suppressive effect of TCDD on beta-catenin in PC12 cells and primary cortical neurons restoring cell viability and protecting cells from apoptosis as compared to untreated controls. Lithium Chloride catenin beta 1 Rattus norvegicus