Title : The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells.

Pub. Date : 2013 Apr 24

PMID : 23618389






3 Functional Relationships(s)
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1 In addition, we identified that amphiregulin (AREG), a down-stream target of YAP which activated EGF receptors (EGFR), mediated an LPA-stimulated and EGFR-dependent long-term (16 hr) cell migration. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
2 In addition, we identified that amphiregulin (AREG), a down-stream target of YAP which activated EGF receptors (EGFR), mediated an LPA-stimulated and EGFR-dependent long-term (16 hr) cell migration. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
3 CONCLUSIONS: A novel LPA-LPA3-G13-RhoA-ROCK-PP1A-dpYAP-AREG-EGFR signaling pathway was linked to LPA-induced migration of EOC cells. lysophosphatidic acid epidermal growth factor receptor Homo sapiens