Pub. Date : 2013 Aug
PMID : 23615401
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells. | Tetradecanoylphorbol Acetate | heme oxygenase 1 | Homo sapiens |
2 | Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products. | Tetradecanoylphorbol Acetate | heme oxygenase 1 | Homo sapiens |
3 | Additionally, induction of HO-1 expression is at least partially involved in the inhibition of TPA-induced MMP-9 activation and cell migration in MCF-7 cells by AP. | Tetradecanoylphorbol Acetate | heme oxygenase 1 | Homo sapiens |