Title : Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells.

Pub. Date : 2013 Aug

PMID : 23615401






3 Functional Relationships(s)
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1 HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells. Tetradecanoylphorbol Acetate heme oxygenase 1 Homo sapiens
2 Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products. Tetradecanoylphorbol Acetate heme oxygenase 1 Homo sapiens
3 Additionally, induction of HO-1 expression is at least partially involved in the inhibition of TPA-induced MMP-9 activation and cell migration in MCF-7 cells by AP. Tetradecanoylphorbol Acetate heme oxygenase 1 Homo sapiens