Title : Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.

Pub. Date : 2013 May 31

PMID : 23612979






2 Functional Relationships(s)
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1 Consistent with this notion, exogenously expressed c-MYC reversed the ability of rapamycin to prevent bortezomib-induced CHOP and ATF4 expression as well as apoptosis. Bortezomib DNA damage inducible transcript 3 Homo sapiens
2 These findings indicate that the induction of ATF4/CHOP expression occurs via mTORC1 regulation of c-MYC and that this signaling pathway is a major determinant in the ability of bortezomib to induce apoptosis. Bortezomib DNA damage inducible transcript 3 Homo sapiens