Pub. Date : 2013
PMID : 23606885
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The chronic administration of allantoin to HFD-fed mice for 8 weeks significantly decreased their body weight, and this effect was reversed by efaroxan at a dose sufficient to block I1R. | Allantoin | nischarin | Mus musculus |
| 2 | The epididymal white adipose tissue (eWAT) cell size and weight in HFD-fed mice were also decreased by allantoin via the activation of I1R. | Allantoin | nischarin | Mus musculus |
| 3 | Moreover, allantoin lowered HFD-induced hyperleptinemia, and this activity was abolished by I1R blockade with efaroxan. | Allantoin | nischarin | Mus musculus |
| 4 | Taken together, these data suggest that allantoin can ameliorate energy intake and eWAT accumulation by activating I1R to improve HFD-induced obesity. | Allantoin | nischarin | Mus musculus |