Title : Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: reversal by celecoxib.

Pub. Date : 2013 Apr

PMID : 23603366






2 Functional Relationships(s)
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1 Celecoxib (10 muM) inhibits COX-1 mediated PGD2, and nitric oxide synthase (NOS) mediated NO in human OA-affected cartilage. Celecoxib latexin Homo sapiens
2 Furthermore, celecoxib (1 muM) counter balances (IL-1beta induced+PGD2 modulated) levels of NO and PGE2 in human OA-affected cartilage and chondrocytes to basal levels. Celecoxib latexin Homo sapiens