Title : Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.

Pub. Date : 2013 Jun 1

PMID : 23602518






1 Functional Relationships(s)
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1 Among the pyridopyrimidine derivatives, 7e and 7l displayed 2.5- and 1.5-fold higher enzyme inhibitory activities against AChE as compared to standard drug, galanthamine, with IC50 of 0.80 and 1.37 muM, respectively. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens