Pub. Date : 2013 Aug
PMID : 23598363
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, the c-Abl kinase inhibitor imatinib mesylate (imatinib) has become the focus of research as a fertoprotective drug against cisplatin. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 2 | We found that, before apoptosis, cisplatin induces c-Abl and TAp73 expression in the oocyte. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 3 | While imatinib was unable to block cisplatin-induced DNA damage and damage response, such as the upregulation of p53, imatinib inhibited the cisplatin-induced nuclear accumulation of c-Abl/TAp73 and the subsequent downregulation of TAp63 and upregulation of Bax, thereby abrogating oocyte cell death. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 4 | The expression kinetics of TAp63, c-Abl and TAp73 suggest that cisplatin activates TAp63-dependent expression of c-Abl and TAp73 and, in turn, the activation of TAp73 by c-Abl-induced BAX expression. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 5 | The expression kinetics of TAp63, c-Abl and TAp73 suggest that cisplatin activates TAp63-dependent expression of c-Abl and TAp73 and, in turn, the activation of TAp73 by c-Abl-induced BAX expression. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 6 | The expression kinetics of TAp63, c-Abl and TAp73 suggest that cisplatin activates TAp63-dependent expression of c-Abl and TAp73 and, in turn, the activation of TAp73 by c-Abl-induced BAX expression. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 7 | Our findings indicate that imatinib protects oocytes from cisplatin-induced cell death by inhibiting c-Abl kinase, which would otherwise activate TAp73-BAX-mediated apoptosis. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 8 | Thus, imatinib and other c-Abl kinase inhibitors provide an intriguing new way to halt cisplatin-induced oocyte death in early follicles and perhaps conserve the endocrine function of the ovary against chemotherapy. | Cisplatin | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |