Pub. Date : 2013 Apr
PMID : 23596468
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide. | Temozolomide | podocalyxin like | Homo sapiens |
| 2 | PODXL overexpression in SW1783 cells significantly increased cell invasion, matrix metalloproteinase-9 (MMP-9) expression, cell survival against temozolomide-induced apoptotic stress, and phosphorylation of Akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (LY). | Temozolomide | podocalyxin like | Homo sapiens |
| 3 | Knockdown of PODXL in U-87 cells significantly decreased cell invasion, MMP-9 expression, cell survival against temozolomide, and phosphorylation of Akt at serine 473 (ser473), which was further decreased by LY treatment. | Temozolomide | podocalyxin like | Homo sapiens |
| 4 | Additionally, PODXL was shown to promote astrocytoma cell survival against temozolomide-induced apoptotic stress by enhancing the activation of the PI3K/Akt survival signaling pathway. | Temozolomide | podocalyxin like | Homo sapiens |