Title : Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death.

Pub. Date : 2013 Apr 17

PMID : 23595764






1 Functional Relationships(s)
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1 The endocytosis of ASIC1a was inhibited by either the small molecular inhibitor tyrphostin A23 or knockdown of the core subunit of adaptor protein 2 (AP2) mu2 using RNA interference, supporting a clathrin-dependent endocytosis of ASIC1a. Tyrphostins acid-sensing (proton-gated) ion channel 1 Mus musculus