Pub. Date : 2013 Jul
PMID : 23594311
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The expression of FasL and activated caspases, particularly caspase-3, was increased, whereas the phosphorylation of PI3K, Akt and NF-kappaB was decreased by GlcN treatment. | Glucosamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Therefore, in addition to down-regulating TCR signalling and promoting CTLA-4 expression, GlcN may also suppress T cell function by enhancing apoptosis of activated T cells, through both extrinsic and intrinsic apoptotic signalling pathways, which were regulated by the inhibition of PI3K/Akt and NF-kappaB phosphorylation. | Glucosamine | AKT serine/threonine kinase 1 | Homo sapiens |