Pub. Date : 2013 Nov
PMID : 23594090
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: To evaluate the therapeutic effect of Simvastatin on apical periodontitis in rats by assessing the osteoblast production of receptor activator of nuclear factor-Kappa B Ligand (RANKL) and Osteoprotegerin (OPG) cytokines that are essential for bone resorption. | Simvastatin | TNF receptor superfamily member 11B | Rattus norvegicus |
| 2 | RESULTS: Simvastatin significantly (P < 0.05) enhanced the expression of OPG and reduced the mRNA expression of RANKL in the experimental group compared with the control group. | Simvastatin | TNF receptor superfamily member 11B | Rattus norvegicus |
| 3 | CONCLUSIONS: Oral administration of Simvastatin attenuated RANKL expression and accelerated OPG expression in induced rat periapical lesions. | Simvastatin | TNF receptor superfamily member 11B | Rattus norvegicus |