Title : Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE(-/-) mice by downregulating the HMGB1-RAGE axis.

Pub. Date : 2013 Jun

PMID : 23564080






1 Functional Relationships(s)
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1 Administration with simvastatin in ApoE(-/-) mice markedly attenuated the vascular inflammation and atherosclerotic lesion area, and decreased the aortic expression of HMGB1, RAGE, VCAM-1, and MCP-1. Simvastatin chemokine (C-C motif) ligand 2 Mus musculus