Pub. Date : 1990 Jan
PMID : 2355308
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Inhibition of cytochrome P-450-dependent monoxygenase activities by a synthetic androgen danazol in mouse hepatic microsomes]. | Danazol | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Addition of danazol to microsomal preparation resulted in a reverse type I difference spectrum and the spectrophotometric analysis revealed that danazol had a high affinity for cytochrome P-450 with dissociation constants (Ks) of 0.9 and 4.2 microM, which were 2 orders of magnitude lower than those of cimetidine. | Danazol | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Addition of danazol to microsomal preparation resulted in a reverse type I difference spectrum and the spectrophotometric analysis revealed that danazol had a high affinity for cytochrome P-450 with dissociation constants (Ks) of 0.9 and 4.2 microM, which were 2 orders of magnitude lower than those of cimetidine. | Danazol | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 4 | These results suggest that danazol is a highly potent inhibitor for several cytochrome P-450-mediated metabolisms of testosterone and xenobiotics in mouse hepatic microsomes. | Danazol | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |