Title : The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.

Pub. Date : 2013 May 10

PMID : 23536184






1 Functional Relationships(s)
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Protein Name
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1 Treatment with camptothecin, a topoisomerase I inhibitor, caused normal cells to down-regulate H2AX and become quiescent, a process mediated by both Arf and p53. Camptothecin tumor protein p53 Homo sapiens