Pub. Date : 2013 Aug
PMID : 23531454
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo. | Dobutamine | high mobility group box 1 | Rattus norvegicus |
| 2 | The present study aimed to investigate whether dobutamine, a selective beta1-adrenergic receptor agonist, could inhibit HMGB1 release via beta1-adrenergic receptor-mediated HO-1 induction and attenuate myocardial ischemia/reperfusion (I/R) injury in rats. | Dobutamine | high mobility group box 1 | Rattus norvegicus |
| 3 | RESULTS: Dobutamine significantly and dose-dependently attenuated myocardial I/R injury, reduced oxidative stress, and caused the induction of HO-1, the reduction of NF-kappaB activation and HMGB1 over expression. | Dobutamine | high mobility group box 1 | Rattus norvegicus |
| 4 | CONCLUSIONS: The present study demonstrated that dobutamine mediated the induction of HO-1 by selectively stimulating beta1-adrenergic receptor via PI3K and p38 MAPK, which inhibited HMGB1 release and attenuated rat myocardial I/R injury in vivo. | Dobutamine | high mobility group box 1 | Rattus norvegicus |