Pub. Date : 2013 Apr
PMID : 23528058
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147. | Propranolol | basigin (Ok blood group) | Homo sapiens |
| 2 | OBJECTIVES: To investigate the role of CD147 in propranolol-induced apoptosis in human umbilical vein endothelial cells (HUVECs). | Propranolol | basigin (Ok blood group) | Homo sapiens |
| 3 | Knocking down CD147 not only induced apoptosis but also exacerbated the apoptosis triggered by propranolol in HUVECs. | Propranolol | basigin (Ok blood group) | Homo sapiens |
| 4 | Overexpression of CD147 can protect HUVECs from apoptosis and propranolol-induced apoptosis. | Propranolol | basigin (Ok blood group) | Homo sapiens |
| 5 | Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway. | Propranolol | basigin (Ok blood group) | Homo sapiens |
| 6 | Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway. | Propranolol | basigin (Ok blood group) | Homo sapiens |
| 7 | CONCLUSIONS: Our studies demonstrate that propranolol-induced apoptosis may be mediated through the downregulation of CD147 in HUVECs. | Propranolol | basigin (Ok blood group) | Homo sapiens |