Title : A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells.

Pub. Date : 2013 May

PMID : 23509080






4 Functional Relationships(s)
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1 Addition of phorbol esters to RPTCs not only increased c-Myc binding to the GRK4 promoter but also increased both phospho-c-Myc and GRK4 expression. Phorbol Esters MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Addition of phorbol esters to RPTCs not only increased c-Myc binding to the GRK4 promoter but also increased both phospho-c-Myc and GRK4 expression. Phorbol Esters MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 The phorbol ester-mediated increase in GRK4 expression was completely blocked by the c-Myc inhibitor, 10074-G5, indicating that GRK4 is downstream of phospho-c-Myc. Phorbol Esters MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 The phorbol ester-mediated increase in GRK4 expression was completely blocked by the c-Myc inhibitor, 10074-G5, indicating that GRK4 is downstream of phospho-c-Myc. Phorbol Esters MYC proto-oncogene, bHLH transcription factor Homo sapiens