Title : Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA.

Pub. Date : 2013 May

PMID : 23507259






1 Functional Relationships(s)
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1 We have examined at the molecular level the crosstalk between these nuclear receptors from the point of view of their control of cell growth and show here that RA reverts estrogen-stimulated transcription of the pivotal anti-apoptotic bcl-2 gene by preventing demethylation of dimethyl lysine 9 in histone H3 (HeK9me2). Tretinoin BCL2 apoptosis regulator Homo sapiens