Pub. Date : 2013 Jun
PMID : 23499166
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells. | Saponins | coagulation factor II, thrombin | Homo sapiens |
| 2 | To determine the effect of its secondary plant metabolites on the endothelium, phenolic compounds and saponins from Butcher"s broom were isolated from a methanolic extract, and their activity on the thrombin-induced hyperpermeability of human microvascular endothelial cells (HMEC-1) was investigated in vitro. | Saponins | coagulation factor II, thrombin | Homo sapiens |
| 3 | The highest activities were observed for the spirostanol saponins 5 and 8 and for esculin (4) at 10muM, and these compounds resulted in a reduction of the thrombin-induced hyperpermeability to 41.9%, 42.6% and 53.3%, respectively. | Saponins | coagulation factor II, thrombin | Homo sapiens |