Title : Different Expression of Extracellular Signal-Regulated Kinases (ERK) 1/2 and Phospho-Erk Proteins in MBA-MB-231 and MCF-7 Cells after Chemotherapy with Doxorubicin or Docetaxel.

Pub. Date : 2012 Jan

PMID : 23493035






3 Functional Relationships(s)
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1 In this study, cytotoxicity and the expression of Erk1/2 and phospho-ERK was compared in MDA-MB-231 (ER-) and MCF-7 (ER+) cell lines after treatment with doxorubicin (DOX) or docetaxel (DOCT). Doxorubicin mitogen-activated protein kinase 3 Homo sapiens
2 In MDA-MB-231 cells the expression of ERK1/2 and phospho-ERK was decreased after DOX treatment in a dose-dependent manner. Doxorubicin mitogen-activated protein kinase 3 Homo sapiens
3 In contrast in MCF-7 cells the expression of ERK1/2 and phospho-ERK was increased after DOX treatment. Doxorubicin mitogen-activated protein kinase 3 Homo sapiens