Title : Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

Pub. Date : 2013 Apr 11

PMID : 23489211






1 Functional Relationships(s)
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1 The l-Trp derivative (20, PCM126) was the most potent antagonist of the series disrupting EphA2-ephrinA1 interaction and blocking EphA2 phosphorylation in prostate cancer cells at low muM concentrations, thus being significantly more potent than LCA. Tryptophan latexin Homo sapiens