Title : Lovastatin-induced decrease of intracellular cholesterol level attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts derived from asthmatic patients.

Pub. Date : 2013 Mar 15

PMID : 23485731






2 Functional Relationships(s)
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1 We demonstrate that the intensity of FMT induced by TGF-beta1 was strongly and dose-dependently attenuated by lovastatin. Lovastatin transforming growth factor beta 1 Homo sapiens
2 Additionally we demonstrate that in bronchial fibroblast populations, both inhibitors (lovastatin and zaragozic acid A) attenuate the TGF-beta1-induced Smad2 nuclear translocation in a manner dependent on intracellular cholesterol level. Lovastatin transforming growth factor beta 1 Homo sapiens