Pub. Date : 2011 Oct 13
PMID : 23483082
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesize that combined EGFR and cyclooxygenase-2 (COX-2) inhibition, using small molecule inhibitors erlotinib and celecoxib, respectively would further increase the antitumor activity of radiotherapy. | Celecoxib | epidermal growth factor receptor | Homo sapiens |
| 2 | Concurrent treatment with celecoxib and erlotinib +- IR inhibited multiple prosurvival proteins including p-ERK1/2, p-EGFR, p-AKT, p-STAT3, COX-2 and PGE-2. | Celecoxib | epidermal growth factor receptor | Homo sapiens |
| 3 | The combination of celecoxib, erlotinib and IR is a promising strategy to overcoming resistance to combined EGFR inhibition and IR alone. | Celecoxib | epidermal growth factor receptor | Homo sapiens |