Title : BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins.

Pub. Date : 2013 May 15

PMID : 23480852






1 Functional Relationships(s)
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1 In the present study we demonstrate that direct inhibition of anti-apoptotic BCL2 proteins with ABT-263 is sufficient to induce C(16)-ceramide synthesis in multiple cell lines, including human leukaemia and myeloma cells. Palmitic Acid BCL2 apoptosis regulator Homo sapiens