Title : DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

Pub. Date : 2013 Jun

PMID : 23466610






5 Functional Relationships(s)
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1 Herein, we report the effects of etoposide and teniposide on macrophage ABCA1 expression and cholesterol efflux. Etoposide ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus
2 Etoposide and teniposide also increased ABCA1 promoter activity in an LXR-dependent manner and formation of the LXRE-LXR/RXR complex indicating that transcriptional induction had occurred. Etoposide ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus
3 In vivo, administration of mice with either etoposide or teniposide induced macrophage ABCA1 expression and enhanced reverse cholesterol transport from macrophages to feces. Etoposide ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus
4 Taken together, our study indicates that etoposide and teniposide increase macrophage ABCA1 expression and cholesterol efflux that may be attributed to the anti-atherogenic properties of etoposide. Etoposide ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus
5 Taken together, our study indicates that etoposide and teniposide increase macrophage ABCA1 expression and cholesterol efflux that may be attributed to the anti-atherogenic properties of etoposide. Etoposide ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus