Title : Nitric oxide attenuates matrix metalloproteinase-9 production by endothelial cells independent of cGMP- or NFκB-mediated mechanisms.

Pub. Date : 2013 Jun

PMID : 23456480






3 Functional Relationships(s)
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1 We studied the effects of DetaNONOate (10-400 muM) or SNAP (50-400 muM) on phorbol 12-myristate 13-acetate (PMA; 10 nM)-induced increases in MMP-9 activity (by gel zymography) or concentrations (by ELISA) as well as on a tissue inhibitor of MMPs" (TIMP)-1 concentrations (by ELISA) in the conditioned medium of HUVECs incubated for 24 h with these drugs. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
2 We studied the effects of DetaNONOate (10-400 muM) or SNAP (50-400 muM) on phorbol 12-myristate 13-acetate (PMA; 10 nM)-induced increases in MMP-9 activity (by gel zymography) or concentrations (by ELISA) as well as on a tissue inhibitor of MMPs" (TIMP)-1 concentrations (by ELISA) in the conditioned medium of HUVECs incubated for 24 h with these drugs. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
3 We also examined whether the irreversible inhibitor of soluble guanylyl cyclase ODQ modified the effects of SNAP or whether 8-bromo-cGMP (a cell-permeable analog of cGMP) influenced PMA-induced effects on MMP-9 expression. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens