Pub. Date : 2013 Jun
PMID : 23452061
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 2 | Our results reveal a novel 5-HT1B receptor-mediated LTD in the NAc and suggest that cocaine exposure may result in elevated phosphorylation of presynaptic proteins involved in regulating glutamate release, which counteracts the presynaptic depressant effects of 5-HT1B receptors and thereby impairs the induction of LTD by 5-HT. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |
| 3 | Our results reveal a novel 5-HT1B receptor-mediated LTD in the NAc and suggest that cocaine exposure may result in elevated phosphorylation of presynaptic proteins involved in regulating glutamate release, which counteracts the presynaptic depressant effects of 5-HT1B receptors and thereby impairs the induction of LTD by 5-HT. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus |