Title : Evaluation of the impact of UGT polymorphism on the pharmacokinetics and pharmacodynamics of the novel PPAR agonist sipoglitazar.

Pub. Date : 2013 Mar

PMID : 23444281






3 Functional Relationships(s)
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1 Model analysis demonstrated UGT2B15 genotype accounted significantly for the variability in sipoglitazar clearance; however, a small fraction of subjects had a clearance that could not be explained entirely by genotype. sipoglitazar UDP glucuronosyltransferase family 2 member B15 Homo sapiens
2 In summary, UGT2B15 genotype is a strong predictor for sipoglitazar clearance; a greater clinical response observed in the UGT2B15*2/*2 genotype appears to confirm this. sipoglitazar UDP glucuronosyltransferase family 2 member B15 Homo sapiens
3 In summary, UGT2B15 genotype is a strong predictor for sipoglitazar clearance; a greater clinical response observed in the UGT2B15*2/*2 genotype appears to confirm this. sipoglitazar UDP glucuronosyltransferase family 2 member B15 Homo sapiens