Title : Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells.

Pub. Date : 2013 Feb 27

PMID : 23442976






1 Functional Relationships(s)
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1 The caspase-3 mediated cleavage of Par-4 is blocked by addition of the pan-caspase inhibitor z-VAD-fmk, caspase-3 specific inhibitor Ac-DEVD-CHO, and by introduction of alanine substitution for D131 residue. acetyl-aspartyl-glutamyl-valyl-aspartal caspase 3 Homo sapiens