Title : [Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis].

Pub. Date : 2013 Feb

PMID : 23441447






1 Functional Relationships(s)
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1 Twenty-four hours of treatment with GA (0.5 micromol/L) following transfection with PKM2 siRNA-1 inhibited the vitality of the PC3 cells by 68%, increased their apoptosis, and significantly down-regulated the mRNA and protein levels of c-myc (50% and 35%) and cyclin D1 (60% and 20%) (P < 0.05). gambogic acid MYC proto-oncogene, bHLH transcription factor Homo sapiens