Pub. Date : 2013 Apr
PMID : 23440295
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. | Eflornithine | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. | Eflornithine | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | DFMO treatment leads to the accumulation of the cyclin-dependent kinase inhibitor p27(Kip1) protein and causes p27(Kip1)/Rb-coupled G(1) cell cycle arrest in MYCN-amplified NB tumor cells through a process that involves p27(Kip1) phosphorylation at residues Ser10 and Thr198. | Eflornithine | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | DFMO treatments induced MYCN protein downregulation and phosphorylation of Akt/PKB (Ser473) and GSK3-beta (Ser9), and polyamine supplementation alleviated the DFMO-induced effects. | Eflornithine | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |