Pub. Date : 2013 Apr 29
PMID : 23428510
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein kinase G linked to dopamine D3 receptors in the dorsal striatum controls dopamine release, DeltaFosB expression and locomotor activity after repeated cocaine administration. | Cocaine | protein kinase cGMP-dependent 1 | Homo sapiens |
| 2 | Inhibition of neuronal nitric oxide synthase, cGMP or PKG, stimulation of D3 receptors, and simultaneous inhibition of each of them with D3 receptor stimulation decreased the repeated cocaine-induced increase in dopamine concentrations and locomotor activity. | Cocaine | protein kinase cGMP-dependent 1 | Homo sapiens |
| 3 | Similarly, inhibition of PKG and simultaneous inhibition of PKG with D3 receptor stimulation decreased DeltaFosB immunoreactivity elevated by repeated cocaine administration, however stimulation of D3 receptors alone did not. | Cocaine | protein kinase cGMP-dependent 1 | Homo sapiens |
| 4 | Similarly, inhibition of PKG and simultaneous inhibition of PKG with D3 receptor stimulation decreased DeltaFosB immunoreactivity elevated by repeated cocaine administration, however stimulation of D3 receptors alone did not. | Cocaine | protein kinase cGMP-dependent 1 | Homo sapiens |
| 5 | These findings suggest that activation of PKG after repeated cocaine administration is more sensitive to interact with D3 receptors in the dopamine terminals than those in medium spiny neurons. | Cocaine | protein kinase cGMP-dependent 1 | Homo sapiens |