Title : Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.

Pub. Date : 2013

PMID : 23422659






1 Functional Relationships(s)
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1 Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue, 2-deoxy-2,3-didehydro-N-acetylneuraminic acid, contributed to the development of the first generation anti-neuraminidase drugs, zanamivir and oseltamivir. 2-deoxy-2,3-dehydro-N-acetylneuraminic acid neuraminidase 1 Homo sapiens