Pub. Date : 2013 Apr 15
PMID : 23422094
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 2 | Alkylating agents, such as dacarbazine, exert their antitumor activity by DNA methylation at the O(6)-guanine site, inducing base pair mismatch; therefore, activity of dacarbazine could be enhanced in CRCs lacking MGMT. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 3 | Alkylating agents, such as dacarbazine, exert their antitumor activity by DNA methylation at the O(6)-guanine site, inducing base pair mismatch; therefore, activity of dacarbazine could be enhanced in CRCs lacking MGMT. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 4 | CONCLUSION: Objective clinical responses to dacarbazine in patients with metastatic CRC are confined to those tumors harboring epigenetic inactivation of the DNA repair enzyme MGMT. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |