Title : Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.

Pub. Date : 2013 Mar 1

PMID : 23422093






1 Functional Relationships(s)
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1 CONCLUSION: Treatment with erlotinib combined with celecoxib offers an effective chemopreventive approach through inhibition of EGFR and mTOR pathways, which may serve as potential biomarkers to monitor the intervention of this combination in the clinic. Celecoxib epidermal growth factor receptor Homo sapiens