Pub. Date : 1990 Jun 1
PMID : 2341719
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transcriptional modulation of human IL-6 gene expression by verapamil. | Verapamil | interleukin 6 | Homo sapiens |
| 2 | In sharp contrast, the addition of verapamil to PHA and PMA-stimulated PBMC augmented the mitogen-stimulated increases in nuclear transcription of IL-6-encoding mRNA, steady state levels of IL-6 encoding mRNA, and release of IL-6 bioactivity. | Verapamil | interleukin 6 | Homo sapiens |
| 3 | In sharp contrast, the addition of verapamil to PHA and PMA-stimulated PBMC augmented the mitogen-stimulated increases in nuclear transcription of IL-6-encoding mRNA, steady state levels of IL-6 encoding mRNA, and release of IL-6 bioactivity. | Verapamil | interleukin 6 | Homo sapiens |
| 4 | In sharp contrast, the addition of verapamil to PHA and PMA-stimulated PBMC augmented the mitogen-stimulated increases in nuclear transcription of IL-6-encoding mRNA, steady state levels of IL-6 encoding mRNA, and release of IL-6 bioactivity. | Verapamil | interleukin 6 | Homo sapiens |
| 5 | We suggest that a non-calcium-dependent, IL-6 regulatory factor, absent or inactive in verapamil-treated cultures, inhibits IL-6 gene activation in mitogen-stimulated PBMC. | Verapamil | interleukin 6 | Homo sapiens |
| 6 | We suggest that a non-calcium-dependent, IL-6 regulatory factor, absent or inactive in verapamil-treated cultures, inhibits IL-6 gene activation in mitogen-stimulated PBMC. | Verapamil | interleukin 6 | Homo sapiens |