Title : Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.

Pub. Date : 2013 Apr 1

PMID : 23415083






1 Functional Relationships(s)
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1 Among the synthesized compounds, 5a, 5b and 6c exhibited potent inhibitory Akt phosphorylation effects with IC50 value of 3.1, 2.0 and 3.0 muM, respectively, and their potencies were better than those of three reference compounds miltefosine, perifosine and edelfosine. edelfosine AKT serine/threonine kinase 1 Homo sapiens