Title : Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury.

Pub. Date : 2013 Mar

PMID : 23414569






2 Functional Relationships(s)
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1 Western blot analysis demonstrated that TC enhanced phosphorylation of AMP-activated protein kinase (AMPK) and cAMP responsive element-binding protein (CREB), and increased expression of the CREB target gene product, brain-derived neurotrophic factor. caryophyllene brain-derived neurotrophic factor Rattus norvegicus
2 In rats, post-ischemic treatment with TC decreased cerebral infarct size and edema, and increased phosphorylated CREB and brain-derived neurotrophic factor expression in neurons. caryophyllene brain-derived neurotrophic factor Rattus norvegicus