Title : Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease.

Pub. Date : 2013 Apr

PMID : 23408070






3 Functional Relationships(s)
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1 Donepezil, galantamine and rivastigmine are acetylcholinesterase inhibitors with different pharmacodynamic and pharmacokinetic profiles. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens