Title : Leucine facilitates insulin signaling through a Gαi protein-dependent signaling pathway in hepatocytes.

Pub. Date : 2013 Mar 29

PMID : 23404499






1 Functional Relationships(s)
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1 The leucine-facilitated insulin-induced phosphorylation of Akt at residue 473 was not affected by knocking down the key component of mTORC1 or -2 complexes but was blocked by inhibition of c-Src (PP2), PI3K (LY294002), Galphai protein (pertussis toxin or siRNA against Galphai1 gene, or beta-arrestin 2 (siRNA)). Leucine CREB regulated transcription coactivator 1 Mus musculus