Title : Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate.

Pub. Date : 2013 May

PMID : 23404373






1 Functional Relationships(s)
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1 We describe an approach combining heme iron oxidation with potassium ferricyanide and metabolite profiling to probe the mechanism of MI complex-based CYP3A4 inactivation by the secondary alkylamine drug lapatinib. Heme cytochrome P450 family 3 subfamily A member 4 Homo sapiens