Pub. Date : 2013 Apr
PMID : 23403148
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | One of the key molecules implicated in sPE pathogenesis is heme oxygenase-1 (HO-1), a rate-limiting enzyme that breaks down heme into carbon monoxide (CO), biliverdin and free iron. | Heme | heme oxygenase 1 | Homo sapiens |
| 2 | These collective actions of the heme breakdown metabolites generated by HO-1 offer protection against cytotoxicity, inflammation, hypoxia and other forms of cellular stress that are central to the pathogenesis of sPE. | Heme | heme oxygenase 1 | Homo sapiens |