Pub. Date : 2013
PMID : 23400261
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4 genetic status may be associated with increased vulnerability to the inhibitory effect of calcium-channel blockers on clopidogrel. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | BACKGROUND: Calcium-channel blockers (CCBs) inhibit the CYP3A4 enzyme, which is involved in clopidogrel activation. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | We investigated the relationship between CYP3A4 genotype and the inhibitory effect of CCBs on clopidogrel response. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The number of CYP3A4 (IVS10+12G>A) A-alleles may be associated with an increased vulnerability to the effects of CCBs on clopidogrel response variation. | Clopidogrel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |