Pub. Date : 2012
PMID : 23394447
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Change in nicotine-induced VEGF, PGE2 AND COX-2 expression following COX inhibition in human oral squamous cancer. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | We found that exposure of BHY cells to nicotine (200 microg/mL for 6 hours) resulted in 2.9-fold induction of COX-2 expression as well as a 4-fold increase in VEGF levels compared with a control group. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Pretreatment with celecoxib inhibited nicotine-induced change in the expression of VEGF and COX-2. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | The results suggest that stimulation of COX-2 and VEGF expression can contribute as important factors in the tumorigenic action of nicotine in oral cancer progression. | Nicotine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |