Title : Advancing our understanding of the mechanisms and mediators underlying pain and inflammation.

Pub. Date : 2007 Dec

PMID : 23392784






1 Functional Relationships(s)
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1 Following peripheral trauma or injury, inflammatory mediators such as phospholipase A(2) are upregulated, inducing the release of arachidonic acid, which is then converted to prostanoids such as prostaglandin E(2) (PGE(2)) via the action of the enzyme cyclo-oxygenase (COX)-2. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens