Title : In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19.

Pub. Date : 2013

PMID : 23385314






1 Functional Relationships(s)
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1 Efavirenz was a moderate inhibitor of CYP2C9 (K(i) = 19.46 microM) and CYP2C19 (K(i) = 21.31 microM); and a weak inhibitor of CYP3A (K(i) = 40.33 microM). efavirenz cytochrome P450 family 3 subfamily A member 4 Homo sapiens