Title : Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.

Pub. Date : 2013 Apr

PMID : 23379999






2 Functional Relationships(s)
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1 The exposure of RGC-5 cells to high glucose activated ERK1/2 and JNK MAPK signaling blocking by GPR91 shRNA (P < 0.01). Glucose mitogen-activated protein kinase 3 Mus musculus
2 These results indicate that GPR91 modulates the high glucose-induced VEGF release of RGC-5 cells, possibly by inhibiting ERK1/2 and JNK MAPK signaling. Glucose mitogen-activated protein kinase 3 Mus musculus